MyoSure® tissue removal
An incisionless solution for uterine polyps and fibroids.
A better life is possible with a minimally-invasive, uterine-sparing procedure that removes tissue from the uterus.
Getting to the root of the issue
The MyoSure procedure lets your doctor address the areas of concern while sparing the rest of your uterus.
If you’re having symptoms or concerns with your uterus, your doctor might suggest a hysteroscopy—a procedure that uses a thin camera to look inside your uterus and find out what’s causing your symptoms.
During a hysteroscopy, your doctor may simultaneously perform a MyoSure procedure to remove tissue, such as polyps and fibroids, or sample tissue that may need further examination. Most patients who undergo a MyoSure procedure return to normal activities in one to two days.1
Ask your doctor if the MyoSure procedure is right for you.
Reasons you may get a MyoSure procedure:
Uterine polyps
Uterine fibroids
Uterine tissue impacting fertility
Retained tissue from pregnancy
Endometrial biopsy (tissue sample)
Bleeding postmenopause
The Procedure
Is MyoSure right for you?
The MyoSure procedure is used to address various uterine conditions, while keeping your uterus intact.
During this procedure, your doctor will look inside your uterus using a hysteroscope and thin camera, and use the MyoSure device to remove or sample uterine tissue. Learn more about the conditions and symptoms when your doctor might use a MyoSure procedure.
Uterine polyps
Uterine polyps
Also called endometrial polyps, uterine polyps are soft tissue growths that form on the inner lining of the uterus (endometrium), are typically small (a few centimeters), and rarely become larger. They are usually noncancerous, though some may become cancerous or precancerous.
Cause: Uterine polyps form due to the overgrowth of endometrial tissue, which is often influenced by hormonal imbalances.
MyoSure treatment: During a MyoSure hysteroscopic polypectomy, your doctor will look inside your uterus with a hysteroscope and thin camera, while using the MyoSure device to remove uterine polyps.
How big are they?
Uterine polyps can range in size from as small as a sesame seed to as large as a golf ball.
Where are they located?
Uterine polyps develop on the inner lining of uterine cavity (endometrium).
Who do they affect?
Uterine polyps may affect women of all ages, and are often found when women are trying to conceive, or during and after menopause.
Common Polyp Symptoms
Irregular menstrual period
Heavy menstrual bleeding
Bleeding in between periods
Infertility
Bleeding after menopause
Bleeding after intercourse
Uterine Polyps: Causes, Symptoms, Diagnosis & Treatment. Cleveland Clinic. https://my.clevelandclinic.org/health/diseases/14683-uterine-polyps. Accessed August 2025.
Uterine fibroids
Uterine fibroids
Also referred to as leiomyomas or myomas, fibroids are muscle growths (noncancerous tumors) that develop in or around the uterus and vary greatly in size, sometimes becoming very large. Fibroid symptoms and their treatment depend on size and location.
Cause: The cause of fibroids isn’t well understood, but it is believed that they form when a cell goes rogue and replicates over time.
MyoSure treatment: Your doctor may recommend the MyoSure procedure for fibroids located inside the uterine cavity based on their size and location. During a MyoSure hysteroscopic myomectomy, your doctor will look inside your uterus with a hysteroscope and thin camera, while using the MyoSure device to remove fibroids.
Discover other minimally-invasive treatment options, like Sonata and Acessa fibroid ablation.
Common Fibroid Symptoms
Heavy menstrual bleeding
Abdominal bloating and cramping
Pelvic, back, and leg pain
Pain during sex
Frequent urination
Fatigue
Uterine Fibroids: Causes, Symptoms & Treatment. Cleveland Clinic. https://my.clevelandclinic.org/health/diseases/9130-uterine-fibroids. Accessed August 2025.
Uterine tissue impacting fertility
Uterine tissue impacting fertility
Several factors can disrupt fertility, including ovulation disorders, damage to fallopian tubes, endometriosis, or various uterine conditions, including polyps and fibroids.
Causes: Common uterine conditions like polyps, fibroids, or irregularities in the uterus can interfere with the egg implanting or increase the risk of miscarriage. Many patients may not realize they have polyps or fibroids until they begin trying to conceive.
MyoSure treatment: Your doctor may recommend the MyoSure procedure depending on the cause of your infertility. During a MyoSure procedure, your doctor will look inside your uterus with a hysteroscope and thin camera, while using the MyoSure device to remove problematic tissue that may be impacting your fertility.
Female infertility. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/female-infertility/symptoms-causes/syc-20354308. Accessed August 2025.
Retained tissue from pregnancy
Retained tissue from pregnancy
Tissue remaining in the uterus from a pregnancy is medically referred to as retained products of conception (RPOC).
Causes: This occurs when pregnancy tissue is left in the uterus from a miscarriage, abortion, or giving birth (either vaginally or a c-section). The tissue may be from the placenta, fetus or embryo.
MyoSure treatment: During a MyoSure procedure, your doctor will look inside your uterus with a hysteroscope and thin camera, while using the MyoSure device to remove retained tissue from pregnancy.
Retained Products of Conception (RPOC): Causes, Risks & Treatment. Cleveland Clinic. https://my.clevelandclinic.org/health/diseases/21512-retained-products-of-conception. Accessed August 2025.
Endometrial biopsy (tissue sample)
Endometrial biopsy (tissue sample)
An endometrial biopsy is a procedure during which your doctor will remove a small piece of the endometrial lining for further examination.
Why: Some reasons for endometrial biopsy may include irregular periods, bleeding after menopause, thickened uterine lining or an irregular pap smear result.
A biopsy is used to investigate abnormal uterine bleeding, check for signs of infection or inflammation, and look for abnormal cells, such as precancerous changes or uterine cancer. A tissue sample may also help diagnose the reason for infertility or repeated miscarriages.
MyoSure treatment: During a MyoSure procedure, your doctor will look inside your uterus with a hysteroscope and thin camera, while using the MyoSure device to collect a small piece of the endometrial lining. The collected tissue is sent to be examined and tested to determine diagnosis and next steps.
Endometrial Biopsy. Cleveland Clinic. https://my.clevelandclinic.org/health/diagnostics/15676-endometrial-biopsy. Accessed August 2025.
Postmenopausal bleeding
Postmenopausal bleeding
Postmenopausal bleeding is any vaginal bleeding that happens after you have gone through menopause, which is when your periods have stopped for at least 12 months. Bleeding can range from light spotting to a heavier flow, but any bleeding that occurs after menopause is considered abnormal.
Causes: Many causes of postmenopausal bleeding may be harmless, like vaginal dryness or hormonal changes. However, it could also be a sign of polyps, fibroids, or in rare cases, uterine cancer.
MyoSure treatment: Your doctor may recommend the MyoSure procedure depending on the cause of your postmenopausal bleeding.
During a MyoSure procedure, your doctor will look inside your uterus with a hysteroscope and thin camera, while using the MyoSure device to either remove polyps and fibroids (that may be causing your bleeding), or take a sample of your endometrial lining. The tissue sampled is sent to be examined and tested to determine diagnosis and next steps.
Postmenopausal Bleeding: Causes, Diagnosis & Treatment. Cleveland Clinic. https://my.clevelandclinic.org/health/diseases/21549-postmenopausal-bleeding. Accessed August 2025.
The MyoSure procedure, at-a-glance
MyoSure is an incisionless, non-hormonal procedure used to remove or sample tissue and is performed with a hysteroscope and camera, so your doctor can see inside your uterus. This procedure can help relieve symptoms, while keeping your uterus intact and allowing for potential fertility.
Could the MyoSure procedure be right for you?
What does it treat?
Uterine polyps and fibroids, retained tissue from pregnancy, and bleeding postmenopause
Who is a candidate?
A doctor can help determine if a MyoSure procedure is right for treating your uterine conditions
How does it work?
Tissue is located with a hysteroscope and camera while the MyoSure device is used to remove it
What does recovery look like?
Patients resume normal activities in 1-2 days1
Are patients satisfied?
89.2% reported satisfaction rate7
The MyoSure procedure, step-by-step
Before starting the procedure, your doctor will issue a pregnancy test to ensure you’re not pregnant.
1. Insert and identify
The cervix is dilated and a hysteroscope and thin camera are inserted into the uterus to locate tissue that may need to be removed or sampled.
2. Access tissue
Once the tissue is located, a MyoSure device is inserted through the hysteroscope to access the tissue that needs to be removed.
3. Remove tissue
The opening of the MyoSure device moves back and forth, resecting and removing the targeted tissue from the uterus.
4. End of procecdure
Once the tissue is resected, the equipment is removed from the uterus, and the collected tissue may be sent for further examination.
Why is visualization important?
Believe it or not, some common procedures—like dilation and curettage (D&C)—collect tissue without seeing inside the uterus. This approach can make it harder to be precise, which could lead to insufficient tissue collection and the need for further tests or procedures.
With a visualized procedure, like MyoSure, your doctor uses a camera to see inside the uterus as they remove tissue. This allows them to work more accurately, helping you get answers sooner and often reducing the need for repeat procedures.
Testimonials
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“The MyoSure procedure was quick, painless, and I was right back to my daily activities.“
MyoSure Patient
Better is possible™
With the MyoSure procedure you can keep your uterus intact and return to normal activities in one to two days.1
MyoSure tissue removal procedure
The MyoSure procedure is designed to see and treat common uterine conditions like polyps, fibroids or retained tissue.
Whether MyoSure is right for you depends on your symptoms, your diagnosis, and your individual health needs.
Other treatment options
Depending on your uterine conditions or symptoms, other treatment options may be right for you, such as, medication, endometrial ablation (NovaSure), fibroid ablation (Sonata, Acessa), myomectomy, uterine artery embolization, and hysterectomy.
Your doctor can help you decide if the MyoSure procedure or another treatment is right for you.
You have options
If you’re feeling unsure about what to do next or need help finding a doctor, don’t worry–we’ve got you covered.
Find Relief with MyoSure
Locate a MyoSure physician near you
Prepare for Your Visit
Bring up these questions and topics with your physician
Assess Your Period
Find out if your period is actually ‘normal’
Go Back to Basics
Understand the symptoms and causes of abnormal uterine bleeding (AUB)
Frequently Asked Questions
Is a MyoSure tissue removal procedure right for me?
The MyoSure tissue removal procedure may be used to remove uterine tissue such as uterine polyps, and fibroids, or tissue retained from pregnancy. Whether MyoSure is right for you depends on your symptoms, your diagnosis, and your individual health needs.
The MyoSure tissue removal procedure is not appropriate for patients who are or may be pregnant, or have signs or symptoms of a pelvic infection, cervical cancer, or previously diagnosed uterine cancer.
Only your doctor can determine if you are a candidate for a MyoSure tissue removal procedure.
How long is a MyoSure tissue removal procedure?
Most MyoSure tissue removal procedures only take around 15 minutes or less.2, 3, 4, 5, 6
Can I still become pregnant after a MyoSure tissue removal procedure?
Treatment with the MyoSure system removes unwanted uterine tissue while preserving the uterus and does not eliminate the possibility of pregnancy. Remember to always talk to your doctor about your pregnancy plans when considering treatment options and ask questions specific to your fertility. For some women experiencing infertility due to unwanted tissue in the uterus, your doctor may recommend MyoSure tissue removal as a treatment option.
Should I have my polyps/fibroids removed before trying to get pregnant?
It is possible to become pregnant with the presence of polyps or fibroids, but studies show that removal of polyps and fibroids hysteroscopically can increase your chances of pregnancy.9,10
Consult with your doctor about your treatment options.
What can I expect after the MyoSure tissue removal procedure?
After a MyoSure hysteroscopic myomectomy you may experience vaginal bleeding or spotting that could last several weeks and/or mild to moderate cramps. Your doctor may recommend over-the-counter non-steroidal anti-inflammatory drugs (NSAIDs) like Tylenol or Motrin.11 Most patients can expect one to two days of recovery and can return to work as soon as they feel ready to do so.12
After a MyoSure hysteroscopic polypectomy you will likely return home the same day, and full recovery is just a matter of days. Your doctor may prescribe an over-the-counter pain medication like Tylenol or Motrin if you are experiencing pain. You may also experience light vaginal bleeding and/or cramps for one to two days. 10,13
What are the risks of a MyoSure tissue removal procedure?
As with any surgical procedure, there are potential risks including but not limited to internal injury, excessive bleeding, and complications related to anesthesia. Temporary side effects may include cramping, bleeding, fever, and nausea.
Talk to your doctor about the benefits, risks and alternatives prior to having a MyoSure tissue removal procedure.
Are patients satisfied with the MyoSure tissue removal procedure?
Patient satisfaction with MyoSure is high – over 97% of women who have had a MyoSure tissue removal procedure are likely to recommend the procedure to a friend. Additionally, 95.2% of women are happy to consider a repeat procedure in the future if required.*,8
What’s the difference between polyps and fibroids?
Polyps and fibroids are uterine growths that differ in tissue type, size, and symptoms. Polyps are soft tissue growths that develop on the endometrial lining, are typically small (a few centimeters), and rarely become larger. Whereas fibroids are muscle growths that develop in or around the uterus and vary greatly in size, sometimes becoming very large.
Will my fibroids and/or polyps grow back after a MyoSure tissue removal procedure?
Uterine polyps rarely grow back.14
There is a chance that your fibroids will grow back and repeat procedures may be necessary, however, one study shows that 95.2% of women are happy to consider a repeat procedure in the future if one is required.8
The only way to ensure permanent elimination of fibroids is to have a hysterectomy, which is the surgical removal of your entire uterus15, but there are also other options that may better manage your fibroid symptoms. Learn more about your treatment options.
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* Based on results that included 42 patients
References
- Hysteroscopy. Mount Sinai Health System, www.mountsinai.org/health-library/surgery/hysteroscopy. Accessed August 2025 ↩︎
- Hologic data on file, VER-04869 ↩︎
- Hologic data on file, VER-13652 ↩︎
- Hologic data on file, VER-11742 ↩︎
- Hologic data on file, VER-11786 ↩︎
- Hologic data on file, VER-11576 ↩︎
- AS;, Rubino RJ;Lukes. “Twelve-Month Outcomes for Patients Undergoing Hysteroscopic Morcellation of Uterine Polyps and Myomas in an Office or Ambulatory Surgical Center.” Journal
of Minimally Invasive Gynecology, U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/25446547/. Accessed 8 Sept. 2023 ↩︎ - . McIlwaine P, McElhinney B, Karthigasu KA, Hart R. A prospective study of the use of the Myosure resectoscope to manage endometrial polyps in an outpatient setting. Aust N Z J Obstet
Gynaecol. 2015 Oct;55(5):482-6. doi: 10.1111/ajo.12382. Epub 2015 Aug 11. PMID: 26259638 ↩︎ - Chen, S, et al. “Fertility after Myomectomy With the MyoSure® Hysteroscopic Tissue Removal System.” Journal of Minimally Invasive Gynecologuy, vol. 22, no. 6, 2015. 191 ↩︎
- Nijkang, Njume Peter, et al. “Endometrial Polyps: Pathogenesis, Sequelae and Treatment.” SAGE Open Medicine, U.S. National Library of Medicine, 2 May 2019, pmc.ncbi.nlm.nih.gov/
articles/PMC6501471/ ↩︎ - Patient Information Sheet. AAGL ↩︎
- Myomectomy. Johns Hopkins Medicine. www.hopkinsmedicine.org/health/treatment-tests-and-therapies/myomectomy-hysteroscopic-laparoscopic-abdominal. Accessed August 2025 ↩︎
- Polypectomy: Definition, Preparation, Procedure & Recovery. Cleveland Clinic. my.clevelandclinic.org/health/treatments/23479-polypectomy. Accessed August 2025 ↩︎
- Uterine polyps: Causes, symptoms, diagnosis & treatment. Cleveland Clinic. https://my.clevelandclinic.org/health/diseases/14683-uterine-polyps. Accessed August 2025 ↩︎
- Uterine fibroids FAQs. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/uterine-fibroids/multimedia/vid-20538086. Accessed August 2025 ↩︎
Important Safety Information
Intended Use: The MyoSure System is intended for diagnostic intrauterine imaging and transcervical treatment of symptomatic uterine fibroids, including those associated with heavy menstrual bleeding.
Contraindications: Current pregnancy; active pelvic infection; known or suspected gynecologic malignancy or premalignant disorders such as atypical endometrial hyperplasia; presence of one or more intratubal implants for sterilization; and presence of an intrauterine device (IUD), unless removed prior to the introduction of the MyoSure Treatment Device.
Anticipated Postoperative Events: abdominopelvic pain/cramping; back pain; constipation; dizziness/fatigue; headache; fever; malaise; nausea/vomiting; sloughing and, less commonly, intact expulsion of ablated fibroid tissue per vaginam (particularly after treatment of submucous fibroids), post-ablation inflammatory symptoms; and vaginal spotting/bleeding/dysmenorrhea. Potential Risks associated with fibroid ablation using the MyoSure System include: allergic reactions (including rash) to device materials; bowel or bladder perforation; cervical/vaginal laceration or tear; dysmenorrhea; electrical shock; hematometrium; hemorrhage; infections: major and minor local and systemic infections, including intrauterine infection; retention of device fragment; skin burn from the dispersion of radiofrequency energy; thrombotic events; unintended injury to the uterus, cervix or vaginal vault, adjacent organs or tissue; unknown risk to future pregnancies; and complications including death.
Pregnancy: Safety and effectiveness with regard to fertility and fecundity after use of the MyoSure System have not been established. As a uterus-conserving alternative to hysterectomy, treatment with the MyoSure System does not eliminate the possibility of pregnancy.
Adenomyosis: Effectiveness in women with clinically significant adenomyosis has not been established.
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